TIDE web server retired and the next generation CIDE
The web server supporting TIDE is permanently down. The next generation for TIDE modules (Query Gene, Regulator Prioritization, and Biomarker Evaluation) are published as the Cancer Immunology Data Engine (CIDE, https://cide.ccr.cancer.gov) in Cell 2025 and permanently maintained at the National Cancer Institute, National Institutes of Health, USA. Moreover, CIDE has many new data resources and analytical capabilities that will help your research. The TIDE Response Prediction module is available as a Python package TIDEpy.
Web address
Citation of CIDE
Cell. 2025 Sep 4;188(18):5062–5080.e32
Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy
Lanqi Gong, ......, Peng Jiang (lead contact:
or
)
Citation of TIDE
Nature Medicine. 2018 Oct;24(10):1550-1558.
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
Peng Jiang, ......, Xiaole Shirley Liu
Thank you for your longstanding support of TIDE. We hope you find the next-generation tools valuable for your research.
Sincerely, Peng Jiang (Lab Website, Google Scholar)